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Postdoctoral Fellow in Preclinical Immuno-Oncology

Compass Therapeutics is a fully-integrated drug discovery and development company focused on manipulating the immune system to treat human disease using our proprietary Targeted Immunomodulation™ platform.  Compass is initially focused on developing cures for cancer by comprehensively drugging the entire tumor-immune synapse with combination therapies. Novel scientific insights are validated and explored deeply inside our labs before Compass pursues the best proprietary combinations of therapeutics into human clinical trials.

Compass has attracted $170M in Series A financing to fund our ambitious plan to build a fully- integrated biopharmaceutical company from the ground up. Our investors are among the most sophisticated venture capitalists in the industry who exemplify our philosophy of building long term economic value through our therapeutic pipeline. They include OrbiMed Advisors, F-Prime Capital, Borealis Ventures, Thiel Capital, Cowen Private Investments, GV, and Alexandria Real Estate Ventures.

Our Translational Immunology group is seeking a unique Postdoctoral Fellow in Preclinical Immuno-Oncology at our Cambridge, MA site.

Basic Description:

The successful candidate will design and execute experiments to identify the cellular and molecular determinants of sensitivity/resistance to cancer immunotherapy in mouse tumor models. This position will require extensive in vivo tumor model work, with deep ex vivo characterization of tumor-infiltrating leukocytes, cancer cells, and stromal cells using a wide variety of techniques (gene profiling, flow cytometry, multiplex cytokine/chemokine profiling, immunohistochemistry, etc.).

Based on their findings, the incumbent will form biomarker hypotheses for indication selection and patient stratification in the clinic. This will involve interrogating the translatability of mouse data to humans through the analysis of candidate biomarker expression using publicly available gene expression databases and from the hands-on study of human primary tumor tissues and blood.

In this high-impact role, the incumbent will have the opportunity to elucidate the mechanism of action for a wide-range of therapeutic strategies, including novel immuno-oncology combinations, and to propose data-driven ideas for novel therapeutic concepts, combinations, and drug discovery programs.

Compass has assembled a world-class team of scientists who are wholly focused on the eradication of cancer and other diseases through modulation of the immune system. The successful candidate’s technical skills and scientific knowledge will be further developed by continuous learning and training at Compass.

Compass expects all Postdoctoral Fellows to publish their findings in high-impact journals and present their work at scientific conferences.

Basic Qualifications:

  • Ph.D. related to the field of Immunology
  • Broad understanding of tumor immunology & immune evasion mechanisms
  • Experience studying immunotherapies in mouse tumor models and ex vivo analyses by FACS, mRNA profiling, and/or other methods

We believe that science is bigger than any one person. Our legacy is what we achieve together. To that end, Compass Therapeutics offers individually-tailored compensation packages which include competitive cash compensation, meaningful equity participation, comprehensive healthcare and adoption benefits, continuous career development, sabbatical programs, education reimbursement and many other benefits aligned with our philosophy of putting our team first. Our labs are located at 245 First Street, Cambridge, MA.

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